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KMID : 0363420170310020048
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Journal of Korean Oriental Pediatrics
2017 Volume.31 No. 2 p.48 ~ p.56
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A Comparative Study of Hataedock versus Probiotics on Immunomodulating Effect in Intestinal Mucosa
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Ahn Sang-Hyun
Cha Ho-Yeol
Kim Ki-Bong
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Abstract
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Objectives: Hataedock is a treatment that dispels toxic heat and meconium which has been accumulated to the fetus from
a pregnant mother via orally administering herbal extracts to a newborn baby. This study was conducted to compare the efficacy of Hataedock, with using the extract of Coptis japonica & Glycyrrhiza uralensis, to the early administration of probiotics for immunomodulation in the intestinal mucosa.
Methods: NC/Nga mice were divided into three groups; Control group (no treatment), CGT group (3-week-old mice given
the extract of Coptis japonica & Glycyrrhiza uralensis), and MBT group (3-week-old mice given a Bifidobacterium). After 2 weeks, the intestinal mucosa tissues of each group of mice were observed. Immunohistochemical staining for IL-4, IL-13, CD40, FcεRI, p-IκB, EGF, and VEGF in the intestinal mucosa was performed.
Results: CGT group showed 65% decrease in IL-4, 67% decrease in IL-13, 58% decrease in CD40, 72% decrease in
Fc?RI, 76% decrease in p-IκB, 41% increase in EGF and 100% increase in VEGF compared to the control group. MBT group also showed 50% decrease in IL-4, 63% decrease in IL-13, 33% decrease in CD40, 53% decrease in Fc?RI, 46% decrease in p-IκB, 23% increase in EGF and 151% increase in VEGF compared to the control group.
Conclusions: These results suggest that both Hataedock, with using the extract of Coptis japonica & Glycyrrhiza uralensis, and early administration of probiotics were effective in regulating Th2, relieving inflammation and developing intestinal
mucosal tissues. Hataedock with extract of Coptis japonica & Glycyrrhiza uralensis may be more effective for immunomodulation in intestinal mucosa than probiotics.
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KEYWORD
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Hataedock, Intestine, Probiotics, Th2 skewed condition, Inflammation
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